WebJan 9, 2024 · A novel ANO5 splicing variant in a LGMD2L patient leads to production of a truncated aggregation-prone Ano5 peptide. Jing Xu, Jing Xu. Division of Cardiovascular Medicine, Department of Cardiac Surgery, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA ... WebProtein aggregation is a major impediment to the development of lead biomolecules into effective biotherapeutics. Schrödinger’s AggScore predicts aggregation propensities by taking into account residue contributions to charged and hydrophobic patch regions projected onto the surface of three-dimensional input structures.
Aggregating sequences that occur in many proteins …
WebSep 9, 2024 · The so-called grafted amyloid-motif antibodies (or gammabodies) represent a valuable alternative class of anti-aggregation antibodies. Gammabodies are single domain human antibodies, where the complementarity-determining regions are replaced by aggregation-prone sequences from amyloidogenic proteins . They then act as β … WebNov 22, 2024 · The protein aggregation is one of the major challenges of the biotechnological industry, especially in the areas of development and … the advantages of e-books
The effect of mutation on an aggregation-prone protein: …
WebApr 14, 2024 · Protein aggregation is a hallmark of multiple human pathologies. Autophagy selectively degrades protein aggregates via aggrephagy. How selectivity is achieved has been elusive. Here, we identify the chaperonin subunit CCT2 as an autophagy receptor regulating the clearance of aggregation-prone proteins in the cell and the mouse brain. WebJan 10, 2013 · Aggregation and immunogenicity constitute major bottlenecks during the discovery and development stages of biotherapeutics. It has been shown that … WebThe aggregation of protein therapeutics such as antibodies remains a major challenge in the biopharmaceutical industry. The present study aimed to characterize the impact of the protein concentration on the mechanisms and potential pathways for aggregation, using the antibody Fab fragment A33 as the … the french football team