Circhif1a
WebJun 12, 2024 · Candidate circHIF1A (circ_0032138) was screened out and it was confirmed that circHIF1A was up-regulated in the exosomes from hypoxic CAFs and their … WebJun 3, 2024 · Posttranscriptional tRNA modifications are essential for proper gene expression, and defects in the enzymes that perform tRNA modifications ar ...
Circhif1a
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WebMar 10, 2024 · Epithelial-to-mesenchymal transition (EMT) is a dynamic program of cell plasticity aberrantly reactivated in cancer. The crosstalk between tumor cells and the tumoral microenvironment (TME) has a pivotal importance for the induction of the EMT and the progression toward a malignant phenotype. Notably, exosomes are key mediators of this … WebJul 28, 2024 · In another study, exosomal circHIF1A significantly promoted triple negative breast cancer growth. An exosomal circHIF1A/NFIB/FUS feedback loop was validated by Chen et al., as exosomal circHIF1A modulated the expression and translocation of NFIB through post-transcriptional and post-translational modification.
WebThe breast cancer cells were used to establish the models in BALB/C nude mice and hypoxia exosomes with circHIF1A shRNA or the controls were injected into the nude … WebHIF1A. Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 ( HIF-1) that is encoded by the HIF1A gene. [5] [6] [7] The Nobel Prize in …
WebMay 10, 2024 · So, circHIF1A could be a novel biomarker for the diagnosis and therapeutic target of TNBC . Epithelial-mesenchymal transformation (EMT) is a fundamental level in TNBC metastasis. Epithelial-mesenchymal transformation (EMT) is a fundamental level in TNBC metastasis. WebcircHIF1A-miRNA-149-5p Interaction with NFIB: Promotion of cell proliferation and metastasis: 0.897: Chen 2024 : Table 2. Summary of the prognostic and predictive role of blood circulating ncRNAs for TNBC (AUC—area under the ROC, CR—complete response, HR—hazard ratio, OR—odds ratio, OS—overall survival, PD—progressive disease, PR ...
WebMechanistically, circHIF1A modulated the expression and translocation of NFIB through posttranscriptional and posttranslational modifications, resulting in the activation of the … ioffice sign inWebLoop is the open research network that increases the discoverability and impact of researchers and their work. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. ioffice ssoWebAug 29, 2024 · We previously reported that circHIF1A could facilitate TNBC proliferation and metastasis by increasing the expression level of NFIB . However, the functions and underlying mechanisms of circRNAs in regulating chemoresistance of TNBC are largely unknown. Therefore, identifying circRNAs that possess regulatory roles in … ioffice status pageWebJun 14, 2024 · [Cell Death Discovery] Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated fibroblasts exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 … ioffice tra vinhFirst, we constructed a circHIF1A overexpression plasmid and designed two small interfering RNAs (siRNAs) targeting the splicing junction of circHIF1A. CircHIF1A overexpression and knockdown efficiencies in TNBC were validated by qRT-PCR (Supplementary Fig. 2A). The expression levels of linear HIF1A … See more Fused in sarcoma (FUS) belongs to the FET family of ubiquitously expressed RNA-binding proteins involved in multiple stages of RNA processing [30, 31]. Recently, FUS was … See more Interestingly, we found that ectopic expression of NFIB could increase circHIF1A expression, while NFIB knockdown led to … See more Because the potential roles of FUS in TNBC progression are largely unknown, we conducted functional experiments with FUS overexpression … See more ioffice toolWebMini-Circuits. Manufacturer Product Number. PHA-1+. Description. IC RF AMP CATV 50MHZ-6GHZ SOT89. Manufacturer Standard Lead Time. 10 Weeks. Detailed … ioffice trà vinhWebAug 20, 2024 · The RNA-binding protein FUS regulates the biogenesis of circHIF1A by interacting with flanking introns, and significantly promotes TNBC growth and metastasis . Go to: 4. Cis-Regulatory Elements. In addition to trans-acting factors that regulate circRNA biogenesis, many cis-regulatory elements can also influence the cyclization of RNA. In ... ioffice-tlc