Cisplatin hearing loss thesis
WebJun 3, 2024 · The topic of my MSc thesis work was “Synthesis and Characterization of CuO-PVA Nanofluid for Heat Transfer Applications”. ... Cisplatin-induced ototoxicity (CIO), manifests as permanent, bilateral, high frequency sensorineural hearing loss that is estimated to affect 26-90% of children that has debilitating effects on children’s ...
Cisplatin hearing loss thesis
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WebImproved survival from childhood cancer has been achieved at the cost of long-term comorbidities that reduce quality of life. The chemotherapy agent cisplatin is essential for treatment of many paediatric and adolescent malignancies but in a large proportion of patients results in cisplatin-induced hearing loss, a debilitating and permanent late … WebMar 26, 2024 · The severity of cisplatin-related ototoxicity is associated with age and the cumulative dose received: the younger the child and the higher the total dose, the more severe the hearing loss may be. The spectrum of hearing loss varies from mild to moderate high tone hearing loss, to profound loss across the hearing range and …
Webhearing loss observed is typically irreversible, progressive, bilateral, high-frequency sensorineural hearing loss associated with tinnitus. At present there is no approved … WebJul 13, 2024 · “Around 60% to 80% of kids who get cisplatin have significant hearing loss,” Dr. Neuwelt explained. The impact of that hearing loss can be profound, he continued, including greatly increasing the risk …
WebBackground: Sensorineural hearing loss is a well-known side effect of cisplatin (CDDP). There is limited research on the effect of dosing, infusion times, and schedules of cisplatin administration and their impact on hearing loss. Methods: A retrospective review of 993 pediatric patients’ medical and audiological WebThis thesis is based on the following original papers, which will be referred to in the text by their Roman numerals I-V. Ekborn A, Laurell G, Andersson A, Wallin I, Eksborg S, Ehrsson H. Cisplatin-induced hearing loss: influence of the mode of drug administration in the guinea pig. Hear Res 2000;140(1-2):38-44.
WebMay 2, 2014 · Cisplatin-induced hearing loss is favoured either by preexisting afflictions like hypoalbuminemia, anaemia, renal failure, and noise-induced hearing loss or by risk …
WebSep 4, 2024 · Scientists have found out why Cisplatin causes hearing loss. Cisplatin is a powerful drug used in some chemotherapy treatments to treat many forms of cancer. Cisplatin and similar platinum-based drugs are prescribed for an estimated 10 to 20 percent of all cancer patients. east bentleigh post codeWebMar 24, 2014 · Detailed Description: The study is a dose-finding study of N-acetylcysteine (NAC) to protect hearing in children receiving cisplatin for the treatment of their cancer. NAC also has potential to protect the kidneys from cisplatin toxicity. The study uses a 3+3 dose-escalation scheme to determine the dose of NAC necessary to achieve serum … cuban housing marketWebHearing loss induced by cisplatin or aminoglycosides is generally bilateral and begins at high frequencies, extend-ing to lower frequencies with prolonged treatment. … east bentleigh postcode victoriaWebCISPLATIN-INDUCED OTOTOXICITY: THE CURRENT STATE OF OTOTOXICITY MONITORING IN NEW ZEALAND _____ A thesis submitted in partial fulfilment of the … cuban houstonWebJan 25, 2024 · More than half of patients treated with cisplatin-based chemotherapy develop hearing loss or tinnitus, which can be devastating, say researchers who urge that all patients should be tested routinely. cuba nightshowWebSynthese und Charakterisierung von neuen Dicobalthexacarbonyl-Komplexen als Cycl... 9 Referenzen [1] Titelblatt east bentleigh poolWeb• Investigating molecular mechanisms underlying cisplatin and noise-induced hearing loss • Determining the role of transplatin as an … cuban iced tea recipe