WebFurther, in patients with p53-inactivated tumors, stabilization of wild-type p53 in normal tissues by MDM2 inhibition might allow selective protection of normal tissues from mitotic … Web1 apr. 1997 · The MDM2 oncoprotein binds to the tumor suppressor p53 and inhibits its anti-oncogenic functions. To determine the amino acids of MDM2 that are critical for binding …

Interactions between p53 and MDM2 in a mammalian cell cycle …

WebOn the other hand, it was hypothesized that the interaction among p53, MDM2 and circFOXO3 may introduce a further protective mechanism against mutant p53. Since … WebCells were collected on day 5 for protein expression analyses. Protein levels of MDM2, p53, and SLC7A11 were determined by Western blot. Each column corresponds to a … how to do numbered pages in word

MDM2 and BCL-2: to p53 or not to p53? Blood American …

Web4 mrt. 2003 · Mdm2, a p53 inducible protein, negatively regulates p53 by inhibiting p53 transcriptional activity and promoting ubiquitin mediated proteasome degradation. The … Web2 okt. 2014 · Finally, the MIP-MDM2 fusion protein, which was collected in the flow through fraction, was further purified by size-exclusion chromatography on a Superdex 75 10/300 … WebThe presence of fusion protein mRNA in these cells was confirmed by RT-PCR ( Fig. 3A ), and, in the case of MLL-ELL and its truncated mutant, by Western blot analysis with a … how to do number citations